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Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2.

Alphaviruses present serious health threats as emerging and re-emerging viruses. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, can cause encephalitis in humans and horses, but there are no therapeutics for treatment. To date, compounds reported as anti-VEEV or anti-alphavirus...

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Principais autores: Dong-Hoon Chung, Colleen B Jonsson, Nichole A Tower, Yong-Kyu Chu, Ergin Sahin, Jennifer E Golden, James W Noah, Chad E Schroeder, Julie B Sotsky, Melinda I Sosa, Daniel E Cramer, Sara N McKellip, Lynn Rasmussen, E Lucile White, Connie S Schmaljohn, Justin G Julander, Jeffrey M Smith, Claire Marie Filone, John H Connor, Yasuteru Sakurai, Robert A Davey
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2014-06-01
Serier:PLoS Pathogens
Online adgang:http://europepmc.org/articles/PMC4072787?pdf=render
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