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Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons

Abstract Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they capture age-associated processes, particularly given that pluripotent cells are only pr...

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Principais autores: Leonard C. Steg, Gemma L. Shireby, Jennifer Imm, Jonathan P. Davies, Alice Franklin, Robert Flynn, Seema C. Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma M. Walker, Leo W. Perfect, Jack Price, Grainne McAlonan, Deepak P. Srivastava, Nicholas J. Bray, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Ehsan Pishva, Emma L. Dempster, Katie Lunnon, Jonathan Mill, Eilis Hannon
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2021-06-01
Series:Molecular Brain
Assuntos:
Epigenetic clock
DNA methylation
Fetal
Neurodevelopment
Induced pluripotent stem cells
iPSC-derived neurons
Acceso en liña:https://doi.org/10.1186/s13041-021-00810-w
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