On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

Disulfide bond reduction, which commonly occurs during monoclonal antibody (mAb) manufacturing processes, can result in a drug substance with high levels of low molecular weight (LMW) species that may fail release specifications because the drug’s safety and the efficiency may be affected by the pre...

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Podrobná bibliografie

Hlavní autoři:	Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Li Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2020-01-01
Edice:	mAbs
Témata:	Antibody disulfide bond redox/reduction/reoxidation low molecular weight Protein A chromatography
On-line přístup:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1829333
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