On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

Disulfide bond reduction, which commonly occurs during monoclonal antibody (mAb) manufacturing processes, can result in a drug substance with high levels of low molecular weight (LMW) species that may fail release specifications because the drug’s safety and the efficiency may be affected by the pre...

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Автори:	Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Li Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Taylor & Francis Group 2020-01-01
Серія:	mAbs
Предмети:	Antibody disulfide bond redox/reduction/reoxidation low molecular weight Protein A chromatography
Онлайн доступ:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1829333
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