Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Analysis of clinically approved antibody-based therapeutics reveals different structural designs, such as full-length IgG1 or Fc-fusions, entail distinct biophysical properties that affect FcRn binding, intracellular transport and plasma half-life.

Opis bibliograficzny

Główni autorzy:	Torleif Tollefsrud Gjølberg, Rahel Frick, Simone Mester, Stian Foss, Algirdas Grevys, Lene Støkken Høydahl, Øystein Kalsnes Jørstad, Tilman Schlothauer, Inger Sandlie, Morten C. Moe, Jan Terje Andersen
Format:	Artigo
Język:	Inglês
Wydane:	Nature Portfolio 2022-08-01
Seria:	Communications Biology
Dostęp online:	https://doi.org/10.1038/s42003-022-03787-x
Etykiety:	Dodaj etykietę Nie ma etykietki, Dołącz pierwszą etykiete!