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NbBayesLM: bayesian prediction of nanobody thermostability using protein language model

Nanobodies, single-domain antibodies derived from camelids, are promising biologics due to their small size and high stability. Accurate prediction of their thermostability is critical for therapeutic and diagnostic applications. Due to their ability to bind conformationally constrained epitopes tha...

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Principais autores: Fairuz Shadmani Shishir, Rokunuzjahan Rudro, Bishnu Sarker, Cuncong Zhong, Sumaiya Shomaji
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Bioinformatics
Fag:
bayesian deep learning
bioinformatics
biomedical AI
nanobody engineering
nanobody thermostability
protein language models
Online adgang:https://www.frontiersin.org/articles/10.3389/fbinf.2026.1832968/full
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