Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists

Background: Bispecific antibodies have emerged as a promising class of therapeutics, enabling simultaneous targeting of two distinct antigens. Single-domain antibodies (sdAbs) comprising camelid variable heavy chains (VHHs) provide a compact and adaptable platform for bispecific antibody design due...

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Auteurs principaux:	Raphael Trenker, Deepti Rokkam, Andrew Morin, Priyanka Balasubrahmanyam, Verenice Paredes, Ivan Cheng, Rene de Waal Malefyt, Martin Oft, Patrick Lupardus, Sandro Vivona
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2025-09-01
Collection:	Antibodies
Sujets:	VHH single-domain antibody bispecific nanobody cytokine surrogate agonist disulfide stapling thermostability
Accès en ligne:	https://www.mdpi.com/2073-4468/14/3/74
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