Computationally guided enzyme engineering for regioselective synthesis of fucosylated human milk oligosaccharides

Abstract Human milk oligosaccharides (HMOs) are key bioactive components of human milk that support infant health and microbiome development. Prevalent HMOs include the internally fucosylated pentasaccharides lacto-N-fucopentaose II (LNFP II) and lacto-N-fucopentaose III (LNFP III), which are absent...

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Autors principals:	Yaya Yang, Aitor Vega, Jesper Holck, Antoni Planas, Xevi Biarnés, Birgitte Zeuner
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer 2026-05-01
Col·lecció:	Applied Microbiology and Biotechnology
Matèries:	Fucosidase Transglycosylation Protein engineering Human milk oligosaccharides Computational design
Accés en línia:	https://doi.org/10.1007/s00253-026-13860-8
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