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Computationally guided enzyme engineering for regioselective synthesis of fucosylated human milk oligosaccharides

Abstract Human milk oligosaccharides (HMOs) are key bioactive components of human milk that support infant health and microbiome development. Prevalent HMOs include the internally fucosylated pentasaccharides lacto-N-fucopentaose II (LNFP II) and lacto-N-fucopentaose III (LNFP III), which are absent...

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Principais autores: Yaya Yang, Aitor Vega, Jesper Holck, Antoni Planas, Xevi Biarnés, Birgitte Zeuner
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2026-05-01
Serier:Applied Microbiology and Biotechnology
Fag:
Fucosidase
Transglycosylation
Protein engineering
Human milk oligosaccharides
Computational design
Online adgang:https://doi.org/10.1007/s00253-026-13860-8
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