The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function

ABSTRACT Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an emerging class of small molecules that disrupt viral maturation by inducing the aberrant multimerization of IN. Here, we present cocrystal structures of HIV-1 IN with two potent ALLINIs, namely, BI-D and the drug candidate Pirmiteg...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Matthew R. Singer, Tung Dinh, Lev Levintov, Arun S. Annamalai, Juan S. Rey, Lorenzo Briganti, Nicola J. Cook, Valerie E. Pye, Ian A. Taylor, Kyungjin Kim, Alan N. Engelman, Baek Kim, Juan R. Perilla, Mamuka Kvaratskhelia, Peter Cherepanov
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology 2023-02-01
Σειρά:	mBio
Θέματα:	antiretroviral drugs HIV-1 integrase allosteric inhibitor ALLINI LEDGIN
Διαθέσιμο Online:	https://journals.asm.org/doi/10.1128/mbio.03560-22
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