Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome

Brugada syndrome (BrS) is an inherited arrhythmogenic disease that may lead to sudden cardiac death in young adults with structurally normal hearts. No pharmacological therapy is available for BrS patients. This situation highlights the urgent need to overcome current difficulties by developing nove...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Vittoria Di Mauro, Paola Ceriotti, Francesco Lodola, Nicolò Salvarani, Jessica Modica, Marie-Louise Bang, Andrea Mazzanti, Carlo Napolitano, Silvia G. Priori, Daniele Catalucci
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2021-01-01
سلاسل:	Frontiers in Physiology
الموضوعات:	brugada syndrome arrhythmia L-type calcium channel mimetic peptide channel trafficking corrective therapy
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fphys.2020.616819/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!