Co-Cultured Continuously Bioluminescent Human Cells as Bioreporters for the Detection of Prodrug Therapeutic Impact Pre- and Post-Metabolism

Modern drug discovery workflows require assay systems capable of replicating the complex interactions of multiple tissue types, but that can still function under high throughput conditions. In this work, we evaluate the use of substrate-free autobioluminescence in human cell lines to support the per...

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Detalles Bibliográficos

Autores principales:	Tingting Xu, Michael Conway, Ashley Frank, Steven Ripp, Gary Sayler, Dan Close
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2017-12-01
Colección:	Sensors
Materias:	bioluminescence bacterial luciferase pharmaceutical development optical imaging
Acceso en línea:	https://www.mdpi.com/1424-8220/17/12/2827
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