Tumor-like proliferation of CCM3 knockout endothelial cells: insights from semaxinib treatment and transcriptome profiling of co-cultures

Abstract Cerebral cavernous malformations (CCMs) are vascular lesions associated with severe neurological complications. Increasing evidence suggests that cancer-like mechanisms, like an abnormal expansion of CCM3 knockout (KO) endothelial cells (ECs) in co-culture with wild-type (WT) cells, contrib...

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Manylion Llyfryddiaeth

Prif Awduron:	Valeriia V. Saenko, Janne L. Feldmann, Dariush Skowronek, Debora Singer, Ole J. Schamuhn, Doreen Biedenweg, Sander Bekeschus, Ute Felbor, Matthias Rath, Robin A. Pilz
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2026-04-01
Cyfres:	Acta Neuropathologica Communications
Pynciau:	Cerebral cavernous malformations CCM3 Endothelial cell Compound screening Semaxinib SU5416
Mynediad Ar-lein:	https://doi.org/10.1186/s40478-026-02283-1
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