SLO co-opts host cell glycosphingolipids to access cholesterol-rich lipid rafts for enhanced pore formation and cytotoxicity

ABSTRACT Streptolysin O (SLO) is a virulence determinant of group A Streptococcus (S. pyogenes), the agent of streptococcal sore throat and severe invasive infections. SLO is a member of a family of bacterial pore-forming toxins known as cholesterol-dependent cytolysins, which require cell membrane...

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Autors principals:	Pooja Sanduja, Stefanie S. Schmieder, Buket Baddal, Songhai Tian, Jorge J. Velarde, Wayne I. Lencer, Min Dong, Michael R. Wessels
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2025-03-01
Col·lecció:	mBio
Matèries:	Streptococcus pyogenes group A Streptococcus streptolysin O toxin cholesterol-dependent cytolysin lipid raft
Accés en línia:	https://journals.asm.org/doi/10.1128/mbio.03777-24
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