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The deubiquitinase OTUD3 plays a neuroprotective role by reducing ferroptosis induced by cerebral ischaemia reperfusion via stabilizing PLK1 via deubiquitination

Abstract Ischaemic stroke is one of the most common serious diseases observed in elderly people, which is caused by ischaemia‐reperfusion (I/R) injury. Ovarian tumour domain‐containing protein 3 (OTUD3) is a member of the ovarian tumour proteases (OTUs) family of deubiquitination enzymes located in...

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Principais autores: Jing Cheng, Qi Tian, Hao‐Ran Lu, Hong‐Xiang Jiang, Xiao‐Hong Qin, Yan‐Qin Fan, Zhi‐Biao Chen, Li‐Quan Wu
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-05-01
Serier:Clinical and Translational Medicine
Fag:
deubiquitination
ischaemia‐reperfusion injury
neuroprotection
OTUD3
PLK1
Online adgang:https://doi.org/10.1002/ctm2.70347
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