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EZH2 Inhibition by DS3201 Triggers the Kaposi’s Sarcoma-Associated Herpesvirus Lytic Cycle and Potentiates the Effects Induced by SAHA in Primary Effusion Lymphoma Cells

Primary Effusion Lymphoma (PEL) cells carry Kaposi’s sarcoma-associated herpesvirus (KSHV) in a latent state, except for a small number of cells in which the virus replicates to ensure its persistence into the infected host. However, the lytic cycle can be reactivated in vitro by exposing these lymp...

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Principais autores: Roberta Gonnella, Flavia Collura, Vincenzo Corrado, Michele Di Crosta, Roberta Santarelli, Mara Cirone
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-09-01
Serier:Viruses
Fag:
KSHV
p53
lytic cycle
autophagy
PEL cells
Online adgang:https://www.mdpi.com/1999-4915/16/9/1490
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