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Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer

Abstract Tumors foster an immunosuppressive microenvironment to evade the antitumor immune response. However, the influence of intratumoral immunosuppressive steroids on tumor-infiltrating natural killer (NK) cells and their implications for effective immunotherapy has remained largely unexplored. H...

Täydet tiedot

Tallennettuna:
Päätekijät: Soura Chakraborty, Jhuma Pramanik, Gustavo Alviter-Raymundo, Christopher J. Ward, Sanu K. Shaji, Yumi Yamashita-Kanemaru, Fatma Abo Zakaib Ali, Debasis Banik, Ziwei Zhang, Clara Veiga-Villauriz, Natalie Z. M. Homer, Joanna Simpson, Sofia Laforest, Shanlin Tong, Qiuchen Zhao, James Roy, Muhammad Iqbal, Andrew Conway Morris, Michael A. Chapman, Rahul Roychoudhuri, Hosni Hussein, David Klenerman, Kourosh Saeb-Parsy, Bidesh Mahata
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2026-04-01
Sarja:Signal Transduction and Targeted Therapy
Linkit:https://doi.org/10.1038/s41392-026-02638-z
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