Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders

Abstract The alpha-synuclein (aSyn) seed amplification assay (SAA) can identify aSyn aggregates as indicator for Lewy body pathology in biomaterials of living patients and help in diagnosing Parkinson´s disease and dementia syndromes. Our objective was to confirm that qualitative results of aSyn SAA...

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Hauptverfasser:	Stefan Bräuer, Marcello Rossi, Johann Sajapin, Thomas Henle, Thomas Gasser, Piero Parchi, Kathrin Brockmann, Björn H. Falkenburger
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-10-01
Schriftenreihe:	Acta Neuropathologica Communications
Schlagworte:	Alpha-synuclein Dementia with Lewy bodies Parkinson’s disease RT-QuIC Seed amplification assay
Online-Zugang:	https://doi.org/10.1186/s40478-023-01653-3
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