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Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

ABSTRACT Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR. Histo-blood group antigen (HBGA) binding assays serve as a proxy...

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Principais autores: Matthew D. Moore, Benjamin G. Bobay, Brittany Mertens, Lee-Ann Jaykus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016-12-01
coleção:mSphere
Assuntos:
aptamer
GII.4
histo-blood group antigen
infectivity
noroviruses
Acesso em linha:https://journals.asm.org/doi/10.1128/mSphere.00298-16
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