Clinical and biological impact of caffeine therapy in premature infants with apnea of prematurity: a prospective observational study

BackgroundMethylxanthines are the first-line medication in apnea of prematurity. However, serum concentrations exhibit marked variability due to immature hepatic metabolism and drug–drug interactions.ObjectivesThis study aimed to evaluate premature newborns diagnosed with apnea of prematurity and hi...

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Detalhes bibliográficos

Principais autores:	Adela-Valeria Neamțu, Ovidiu Mircea Zlatian, Andrei Theodor Bălășoiu, Costel-Valentin Manda, Carla-Maria Bărbulescu-Mateescu, Ana-Maria Pătrașcu, Ramona Cioboată, Liliana Stanca, Olivia Garofița Mateescu, Ștefan Pătrașcu, Antonia Radu, Simona-Daniela Neamțu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Medicine
Assuntos:	apnea of prematurity hypoxia LC-MS methylxanthines therapeutic drug monitoring
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmed.2026.1808401/full
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