Clinical and biological impact of caffeine therapy in premature infants with apnea of prematurity: a prospective observational study

BackgroundMethylxanthines are the first-line medication in apnea of prematurity. However, serum concentrations exhibit marked variability due to immature hepatic metabolism and drug–drug interactions.ObjectivesThis study aimed to evaluate premature newborns diagnosed with apnea of prematurity and hi...

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Autors principals:	Adela-Valeria Neamțu, Ovidiu Mircea Zlatian, Andrei Theodor Bălășoiu, Costel-Valentin Manda, Carla-Maria Bărbulescu-Mateescu, Ana-Maria Pătrașcu, Ramona Cioboată, Liliana Stanca, Olivia Garofița Mateescu, Ștefan Pătrașcu, Antonia Radu, Simona-Daniela Neamțu
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-05-01
Col·lecció:	Frontiers in Medicine
Matèries:	apnea of prematurity hypoxia LC-MS methylxanthines therapeutic drug monitoring
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fmed.2026.1808401/full
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