LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors

Abstract Liver Kinase B1 (LKB1), encoded by Serine-Threonine Kinase 11 (STK11), is a master kinase that regulates cell migration, polarity, proliferation, and metabolism through downstream adenosine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase signalling. Since genetic scree...

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Bibliografske podrobnosti

Principais autores:	Charles B. Trelford, Trevor G. Shepherd
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-06-01
Serija:	Cell Communication and Signaling
Teme:	Tumour Suppressor Liver Kinase B1 (LKB1) STE-20-related Kinase Adaptor Protein (STRAD) Mouse Protein 25 (MO25) Adenosine Monophosphate-Activated Protein Kinase (AMPK) Adenosine Monophosphate-Activated Protein Kinase-related Kinases (ARKs)
Online dostop:	https://doi.org/10.1186/s12964-024-01689-5
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