Increased Resection at DSBs in G₂-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ

The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining ground at doses below 0.5 Gy. Increased resection a...

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Principais autores:	Huaping Xiao, Fanghua Li, Emil Mladenov, Aashish Soni, Veronika Mladenova, Bing Pan, Rositsa Dueva, Martin Stuschke, Beate Timmermann, George Iliakis
格式:	Artigo
语言:	Inglês
出版:	MDPI AG 2022-07-01
丛编:	Cells
主题:	DSB repair DNA-PKcs c-NHEJ DNA end-resection ionizing radiation
在线阅读:	https://www.mdpi.com/2073-4409/11/13/2099
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