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Optimized multi-epitope neoantigen human cytomegalovirus vaccine based on adenovirus vectors elicits potent antiviral immunity

IntroductionHuman cytomegalovirus (HCMV) induces severe morbidity and mortality in neonates, organ transplant recipients, and immunocompromised individuals. Currently, there is no licensed vaccine for HCMV. Given its ability to elicit a robust and enduring CD8 T cell response, we designed a recombin...

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Principais autores: Shasha Jiang, Xianjuan Zhang, Heping Zhao, Fengjun Liu, Zonghui Li, Xiaoli Yang, Wenxuan Liu, Jing Lv, Yi Zhang, Yiran Zhang, Yan Yu, Bin Wang, Yunyang Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-11-01
coleção:Frontiers in Immunology
Assuntos:
human cytomegalovirus
adenovirus vaccine
immune response
memory T cell
mitochondrial biogenesis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1658220/full
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