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A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children

Summary: Hispanic/Latino children have the highest risk of acute lymphoblastic leukemia (ALL) in the US compared to other racial/ethnic groups, yet the basis of this remains incompletely understood. Through genetic fine-mapping analyses, we identified a new independent childhood ALL risk signal near...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Adam J. de Smith, Lara Wahlster, Soyoung Jeon, Linda Kachuri, Susan Black, Jalen Langie, Liam D. Cato, Nathan Nakatsuka, Tsz-Fung Chan, Guangze Xia, Soumyaa Mazumder, Wenjian Yang, Steven Gazal, Celeste Eng, Donglei Hu, Esteban González Burchard, Elad Ziv, Catherine Metayer, Nicholas Mancuso, Jun J. Yang, Xiaomei Ma, Joseph L. Wiemels, Fulong Yu, Charleston W.K. Chiang, Vijay G. Sankaran
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2024-04-01
Rangatū:Cell Genomics
Ngā marau:
acute lymphoblastic leukemia
childhood leukemia
B-ALL
IKZF1
GWAS
fine-mapping
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2666979X24000685
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