Synthesis, biological evaluation, and molecular docking of novel 1,3,4-substituted-thiadiazole derivatives as potential anticancer agent

Abstract In an attempt to develop potent anti-cancer agents, a new 1,3,4-substituted-thiadiazole derivatives (8b-g), starting from 4-substituted-thiazol-2-chloroacetamides (4b-g), were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the hepatocell...

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Principais autores:	Samin A. Shaikh, Satish N. Wakchaure, Shivaji R. Labhade, Raju R. Kale, Rajasekhar R. Alavala, Santosh S. Chobe, Kamlesh S. Jain, Hrishikesh S. Labhade, Dipak D. Bhanushali
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-06-01
coleção:	BMC Chemistry
Assuntos:	Anticancer agents Thiazole-Thiadiazole compounds Antiproliferative activity Synthesis optimization Molecular docking
Acesso em linha:	https://doi.org/10.1186/s13065-024-01196-1
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