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The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification

Abstract Objective For treatment of medication-related osteonecrosis of the jaw, one proposed approach is the use of a topical agent to block entry of these medications in oral soft tissues. We tested the ability of phosphonoformic acid (PFA), an inhibitor of bisphosphonate entry through certain s...

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Principais autores: Jacob KIRBY, Makayla STANDFEST, Jessica BINKLEY, Charles BARNES, Evan BROWN, Tyler CAIRNCROSS, Alex CARTWRIGHT, Danielle DADISMAN, Colten MOWAT, Daniel WILMOT, Theodore HOUSEMAN, Conner MURPHY, Caleb ENGELSMAN, Josh HALLER, Daniel JONES
Format: Artigo
Sprog:Inglês
Udgivet: Faculdade De Odontologia De Bauru - USP 2024-09-01
Serier:Journal of Applied Oral Science
Fag:
Bisphosphonate-associated osteonecrosis of the jaw
Dynamins
Endosomes
Fibroblasts
Zoledronic acid
Online adgang:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572024000100454&lng=en&tlng=en
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