Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway

Abstract Bladder cancer (BLCA) is one of the ten most common cancers worldwide. However, the deregulation of PROS1 and its specific function in BLCA is not well understood. By combining proteomic and transcriptomic datasets, we discovered PROS1 expression was significantly reduced in BLCA tissues an...

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Auteurs principaux:	Xin-peng Fan, Ji-rong Wang, Si-yu Chen, Xiao-ran Li, Jin-long Cao, Hua-bin Wang, Li-yun Ding, Tuan-jie Che, Li Yang
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2025-02-01
Collection:	Scientific Reports
Sujets:	Bladder cancer PROS1 Angiogenesis Bioinformatics Vitro and vivo functional experiment
Accès en ligne:	https://doi.org/10.1038/s41598-025-89217-4
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