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Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway

Abstract Bladder cancer (BLCA) is one of the ten most common cancers worldwide. However, the deregulation of PROS1 and its specific function in BLCA is not well understood. By combining proteomic and transcriptomic datasets, we discovered PROS1 expression was significantly reduced in BLCA tissues an...

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Principais autores: Xin-peng Fan, Ji-rong Wang, Si-yu Chen, Xiao-ran Li, Jin-long Cao, Hua-bin Wang, Li-yun Ding, Tuan-jie Che, Li Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-02-01
coleção:Scientific Reports
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Acesso em linha:https://doi.org/10.1038/s41598-025-89217-4
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