The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin

Abstract Background The huntingtin-associated protein 40 (HAP40) abundantly interacts with huntingtin (HTT), the protein that is altered in Huntington’s disease (HD). Therefore, we analysed the evolution of HAP40 and its interaction with HTT. Results We found that in amniotes HAP40 is encoded by a s...

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Principais autores:	Manuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang Baumeister, Qiang Guo, Rubén Fernández-Busnadiego, Andrei N. Lupas, Stefan Kochanek
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2020-12-01
סדרה:	BMC Evolutionary Biology
נושאים:	Huntingtin Huntingtin-associated protein 40 Soluble N-ethylmaleimide-sensitive factor attachment proteins Retroposition Single-exon gene Molecular evolution
גישה מקוונת:	https://doi.org/10.1186/s12862-020-01705-5
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