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The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin

Abstract Background The huntingtin-associated protein 40 (HAP40) abundantly interacts with huntingtin (HTT), the protein that is altered in Huntington’s disease (HD). Therefore, we analysed the evolution of HAP40 and its interaction with HTT. Results We found that in amniotes HAP40 is encoded by a s...

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Principais autores: Manuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang Baumeister, Qiang Guo, Rubén Fernández-Busnadiego, Andrei N. Lupas, Stefan Kochanek
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-12-01
Colecção:BMC Evolutionary Biology
Assuntos:
Huntingtin
Huntingtin-associated protein 40
Soluble N-ethylmaleimide-sensitive factor attachment proteins
Retroposition
Single-exon gene
Molecular evolution
Acesso em linha:https://doi.org/10.1186/s12862-020-01705-5
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