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Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions

Post translational modifications (PTMs) have been shown to negatively impact protein efficacy and safety by altering its native conformation, stability, target binding and/or pharmacokinetics. One PTM in particular, shuffled disulfide bonds, has been linked to decreased potency and increased immunog...

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Main Authors: Jill Coghlan, Alexander Benet, Preethi Kumaran, Michael Ford, Lawrie Veale, St. John Skilton, Sergei Saveliev, Anna A. Schwendeman
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
disulfide bond shuffling
IgG1 therapeutics
biosimilars
LC-MS/MS
protein degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.862456/full
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