Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions

Post translational modifications (PTMs) have been shown to negatively impact protein efficacy and safety by altering its native conformation, stability, target binding and/or pharmacokinetics. One PTM in particular, shuffled disulfide bonds, has been linked to decreased potency and increased immunog...

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Principais autores:	Jill Coghlan, Alexander Benet, Preethi Kumaran, Michael Ford, Lawrie Veale, St. John Skilton, Sergei Saveliev, Anna A. Schwendeman
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2022-03-01
סדרה:	Frontiers in Bioengineering and Biotechnology
נושאים:	disulfide bond shuffling IgG1 therapeutics biosimilars LC-MS/MS protein degradation
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fbioe.2022.862456/full
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