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Environment shapes gut microbiome and determines susceptibility to DSS-colitis in Adamdec1-/- mice

BackgroundInflammatory bowel disease (IBD) is characterized by marked clinical heterogeneity, reflecting complex interactions between host genetics, environmental exposures, and the gut microbiome. Although over 300 genetic risk loci have been identified, these account for only a fraction of disease...

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Principais autores: Tomoko Kumagai, Silke Rath, Shuangqi Fan, Farooq Z. Rahman, Andrew M. Smith
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-07-01
Serier:Frontiers in Immunology
Fag:
ADAMDEC1
gene-environment interactions
gut microbiome
mucosal inflammation
phenotype variability
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1824007/full
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