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The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging

Abstract Cellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and contributes to poor cell therapy outcomes. Aging tissues are associated with extracellular matrix (ECM) dysregulation, includin...

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Principais autores: Sunny Shinchen Lee, Aleen Al Halawani, Jonathan D. Teo, Anthony S. Weiss, Giselle C. Yeo
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2024-10-01
Serier:Advanced Science
Fag:
aging
fitness
mesenchymal stromal cells
senescence
stem cells
tropoelastin
Online adgang:https://doi.org/10.1002/advs.202402168
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