An explanation for origin unwinding in eukaryotes
Twin CMG complexes are assembled head-to-head around duplex DNA at eukaryotic origins of replication. Mcm10 activates CMGs to form helicases that encircle single-strand (ss) DNA and initiate bidirectional forks. How the CMGs melt duplex DNA while encircling it is unknown. Here we show that S. cerevi...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications Ltd
2019-07-01
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| Schriftenreihe: | eLife |
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| Online-Zugang: | https://elifesciences.org/articles/46515 |
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