Mesenchymal stem cell suppresses the efficacy of CAR-T toward killing lymphoma cells by modulating the microenvironment through stanniocalcin-1

Stem cells play critical roles both in the development of cancer and therapy resistance. Although mesenchymal stem cells (MSCs) can actively migrate to tumor sites, their impact on chimeric antigen receptor modified T cell (CAR-T) immunotherapy has been little addressed. Using an in vitro cell co-cu...

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Principais autores:	Rui Zhang, Qingxi Liu, Sa Zhou, Hongpeng He, Mingfeng Zhao, Wenjian Ma
格式:	Artigo
語言:	Inglês
出版:	eLife Sciences Publications Ltd 2023-02-01
叢編:	eLife
主題:	mesenchymal stem cells CAR-T stanniocalcin-1 cancer therapy macrophages pfeiffer cells
在線閱讀:	https://elifesciences.org/articles/82934
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