A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport.

All animal cells use the motor cytoplasmic dynein 1 (dynein) to transport diverse cargo toward microtubule minus ends and to organize and position microtubule arrays such as the mitotic spindle. Cargo-specific adaptors engage with dynein to recruit and activate the motor, but the molecular mechanism...

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Bibliografische gegevens

Hoofdauteurs:	Ricardo Celestino, Morkos A Henen, José B Gama, Cátia Carvalho, Maxwell McCabe, Daniel J Barbosa, Alexandra Born, Parker J Nichols, Ana X Carvalho, Reto Gassmann, Beat Vögeli
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Public Library of Science (PLoS) 2019-01-01
Reeks:	PLoS Biology
Online toegang:	https://doi.org/10.1371/journal.pbio.3000100
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