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Human Umbilical Cord Mesenchymal Stem Cells Modulate Cytokine Secretion of CD4+ T Cell in Systemic Lupus Erythematosus by Inhibiting HSP90AA1 in the Glucose‐Activated PI3K‐AKT Pathway

ABSTRACT Objective Treatment with human umbilical cord mesenchymal stem cells (hUC‐MSCs) attenuated the clinical manifestations of systemic lupus erythematosus (SLE). We investigated the metabolic mechanism whereby hUC‐MSCs modify CD4+ T cell cytokine secretion in lupus. Methods The study enrolled 3...

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Principais autores: Lu Jin, Meng Ding, Shaoxin Cui, Lin Yang, Jingjing He, Xiaoping Wang, Fei Chang, Jingjing Yu, Yiming Yang, Hongtao Jin, Min Shi, Jun Ma, Aijing Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-08-01
coleção:Immunity, Inflammation and Disease
Assuntos:
CD4+ T cell
cytokine
glucose metabolism
HSP90AA1
Lupus
mesenchymal stem cell
Acesso em linha:https://doi.org/10.1002/iid3.70239
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