Human Umbilical Cord Mesenchymal Stem Cells Modulate Cytokine Secretion of CD4+ T Cell in Systemic Lupus Erythematosus by Inhibiting HSP90AA1 in the Glucose‐Activated PI3K‐AKT Pathway

ABSTRACT Objective Treatment with human umbilical cord mesenchymal stem cells (hUC‐MSCs) attenuated the clinical manifestations of systemic lupus erythematosus (SLE). We investigated the metabolic mechanism whereby hUC‐MSCs modify CD4+ T cell cytokine secretion in lupus. Methods The study enrolled 3...

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Автори:	Lu Jin, Meng Ding, Shaoxin Cui, Lin Yang, Jingjing He, Xiaoping Wang, Fei Chang, Jingjing Yu, Yiming Yang, Hongtao Jin, Min Shi, Jun Ma, Aijing Liu
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Wiley 2025-08-01
Серія:	Immunity, Inflammation and Disease
Предмети:	CD4+ T cell cytokine glucose metabolism HSP90AA1 Lupus mesenchymal stem cell
Онлайн доступ:	https://doi.org/10.1002/iid3.70239
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