Ziyuglycoside II ameliorates chemotherapy-induced neutropenia by promoting neutrophil differentiation and functional recovery via SPI1 and C/EBPϵ transcriptional regulation

BackgroundChemotherapy-induced neutropenia (CIN) remains a major dose-limiting toxicity associated with myelosuppressive chemotherapy regimens. The development of therapeutic strategies capable of effectively restoring neutrophil production and function could address a critical unmet clinical issue....

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Principais autores:	Lingdi Li, Huan Lei, Luqi Chen, Chunye Cao, Haolin He, Yanfeng Zhang, Lin Zhang, Liang Peng, Yuxiu Yang, Yulin Feng, Haihong Fang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-02-01
Series:	Frontiers in Immunology
Assuntos:	C/EBPϵ chemotherapy-induced neutropenia neutrophil differentiation SPI1 transcriptional regulation Ziyuglycoside II
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1771161/full
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