BIGH3 is a mediator of TGFβ-Induced collagen formation in fibrosis and pancreatic cancer and a potential therapeutic target

Abstract Fibroblast-driven deposition of extracellular matrix, particularly type III collagen, is linked to poor outcomes in patients with liver fibrosis, fibrotic solid tumors such as hepatocellular carcinoma and pancreatic cancer as well as in patients with other fibrotic diseases. The pro-peptide...

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Detalhes bibliográficos

Principais autores:	Nicholas Willumsen, Kim Henriksen, Cecilie Bager, Anette T. Hansen Selnø, Khaled E. Mohamed, Diana J. Leeming, Mark Alexander Skarsfeldt, Neel I. Nissen, Rasmus S. Pedersen, Jeppe Thorlacius-Ussing, Morten H. Dziegiel, Man-Hung Eric Tang, Lars N. Jørgensen, Hadi M. H. Diab, Inna M. Chen, Julia S. Johansen, Philip Vitorino, Abby Sarkar, Andrew Bradshaw, Morten A. Karsdal
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-025-24463-0
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