BIGH3 is a mediator of TGFβ-Induced collagen formation in fibrosis and pancreatic cancer and a potential therapeutic target

Abstract Fibroblast-driven deposition of extracellular matrix, particularly type III collagen, is linked to poor outcomes in patients with liver fibrosis, fibrotic solid tumors such as hepatocellular carcinoma and pancreatic cancer as well as in patients with other fibrotic diseases. The pro-peptide...

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Autori principali:	Nicholas Willumsen, Kim Henriksen, Cecilie Bager, Anette T. Hansen Selnø, Khaled E. Mohamed, Diana J. Leeming, Mark Alexander Skarsfeldt, Neel I. Nissen, Rasmus S. Pedersen, Jeppe Thorlacius-Ussing, Morten H. Dziegiel, Man-Hung Eric Tang, Lars N. Jørgensen, Hadi M. H. Diab, Inna M. Chen, Julia S. Johansen, Philip Vitorino, Abby Sarkar, Andrew Bradshaw, Morten A. Karsdal
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-11-01
Serie:	Scientific Reports
Accesso online:	https://doi.org/10.1038/s41598-025-24463-0
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