Integrative genomic analysis reveals low T-cell infiltration as the primary feature of tobacco use in HPV-positive oropharyngeal cancer

Summary: Although tobacco use is an independent adverse prognostic feature in HPV(+) oropharyngeal squamous cell carcinoma (OPSCC), the biologic features associated with tobacco use have not been systematically investigated. We characterized genomic and immunologic features associated with tobacco u...

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主要な著者:	Benjamin M. Wahle, Paul Zolkind, Ricardo J. Ramirez, Zachary L. Skidmore, Sydney R. Anderson, Angela Mazul, D. Neil Hayes, Vlad C. Sandulache, Wade L. Thorstad, Douglas Adkins, Obi L. Griffith, Malachi Griffith, Jose P. Zevallos
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2022-05-01
シリーズ:	iScience
主題:	Oncology Immunology Genomics
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2589004222004862
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