ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma

Summary: Although ACVR2A mutations are prevalent in non-viral hepatocellular carcinomas (HCCs), the underlying mechanism remains unelucidated. Our molecular investigation reveals that ACVR2A impairment induces hyperglycolysis through the inactivation of the SMAD signaling pathway. Using syngeneic tr...

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מידע ביבליוגרפי

Principais autores:	Koya Yasukawa, Shu Shimada, Yoshimitsu Akiyama, Tomohiko Taniai, Yosuke Igarashi, Shu Tsukihara, Yoshiaki Tanji, Kentaro Umemura, Atsushi Kamachi, Atsushi Nara, Masahiro Yamane, Keiichi Akahoshi, Akira Shimizu, Yuji Soejima, Minoru Tanabe, Shinji Tanaka
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-04-01
סדרה:	Cell Reports Medicine
נושאים:	ACVR2A hepatocellular carcinoma PD-1 immunotherapy lactate MCT4
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2666379125001119
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!