Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis

Abstract Background Mesenchymal stromal cells (MSCs) are a potential therapeutic tool for pulmonary fibrosis. However, ex vivo MSC expansion using serum poses risks of harmful immune responses or unknown pathogen infections in the recipients. Therefore, MSCs cultured in serum-free media (SF-MSCs) ar...

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Ngā kaituhi matua:	Shun Takao, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Shinya Takahashi, Ayumu Nakashima, Noboru Hattori
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2021-09-01
Rangatū:	Stem Cell Research & Therapy
Ngā marau:	Mesenchymal stromal cells Serum-free Bleomycin Pulmonary fibrosis Regulatory T cells Interleukin-6
Urunga tuihono:	https://doi.org/10.1186/s13287-021-02574-5
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!