Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis

Abstract Background Mesenchymal stromal cells (MSCs) are a potential therapeutic tool for pulmonary fibrosis. However, ex vivo MSC expansion using serum poses risks of harmful immune responses or unknown pathogen infections in the recipients. Therefore, MSCs cultured in serum-free media (SF-MSCs) ar...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Shun Takao, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Shinya Takahashi, Ayumu Nakashima, Noboru Hattori
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	BMC 2021-09-01
سلاسل:	Stem Cell Research & Therapy
الموضوعات:	Mesenchymal stromal cells Serum-free Bleomycin Pulmonary fibrosis Regulatory T cells Interleukin-6
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13287-021-02574-5
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!