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Increased α-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer.

The controlled formation and stabilization of E-cadherin-based adhesions is vital for epithelial integrity. This requires co-operation between the E-cadherin-based adhesions and the associated actin cytoskeleton. In cancer, this co-operation often fails, predisposing cells to migration through molec...

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書目詳細資料
Principais autores: Bianca Kovac, Tomi P Mäkelä, Tea Vallenius
格式: Artigo
語言:Inglês
出版: Public Library of Science (PLoS) 2018-01-01
叢編:PLoS ONE
在線閱讀:http://europepmc.org/articles/PMC5942811?pdf=render
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