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Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle growth and repair. The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an important transducer of growth factor and cytokine signals. Here we combi...

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Principais autores: Joscha Griger, Robin Schneider, Ines Lahmann, Verena Schöwel, Charles Keller, Simone Spuler, Marc Nazare, Carmen Birchmeier
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2017-05-01
coleção:eLife
Assuntos:
Shp2
Ptpn11
satellite cells
skeletal muscle repair
skeletal muscle growth
quiescence
Acesso em linha:https://elifesciences.org/articles/21552
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