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Characterization of Novel Sigma Receptor Ligands Derived from Multicomponent Reactions as Efficacious Treatments for Neuropathic Pain

<b>Background/Objectives</b>: Neuropathic pain remains a significant clinical challenge, with current treatments often providing inadequate relief and adverse effects. Sigma receptors (SRs) modulate nociception and have emerged as potential therapeutic targets for neuropathic pain. Although putative...

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Hlavní autoři: Ryosuke Shinouchi, Bengisu Turgutalp, Rohini S. Ople, Shainnel O. Eans, Ashai K. Williams, Haylee R. Hammond, Andras Varadi, Rebecca Notis Dardashti, Susruta Majumdar, Jay P. McLaughlin
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2026-01-01
Edice:Pharmaceuticals
Témata:
sigma
neuropathic pain
inflammatory pain
sigma-1 receptor ligand
allodynia
analgesia
On-line přístup:https://www.mdpi.com/1424-8247/19/1/117
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